K T C C 2005

4th International Symposium of Kyoto T Cell Conference

President; Sonoko Habu
Program Committee; Shigeo Koyasu, Nagahiro Minato, Toshinori Nakayama, Takashi Saito, Shimon Sakaguchi, Yousuke Takahama.

The '4th International Symposium of Kyoto T Cell Conference' was held in conjunction with '2005 Workshop of Thymus Organogenesis' and 'Symposium on Immune Tolerance and Regulation'.

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Pictures from the meetings

Additional large picture files

Contribution of additional pictures is highly welcome. Please send the digital files to Y. Takahama.

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at Shiran Kaikan, Kyoto University, Kyoto, Japan

April 6

15:00 Registration

18:00 Welcome remarks
18:05 - 19:30 Keynote lecture, Thomas Boehm (Max-Planck-Institute of Immunobiology) Genetic dissection of thymus development: Uncharted aspects of its phylogeny and ontogeny

20:00 Reception at Hotel Fujita

April 7

[YAMAUCHI HALL]

The organogenesis of the thymus, Chair: Graham Anderson

9:00 - 9:30 Georg Hollander (University of Basel) On the molecular mechanisms of early thymus development
9:30 - 10:00 Andrew Farr (University of Washington) Extrathoracic thymic tissue in the mouse - isnt one thymus enough?
10:00 - 10:15 Norimasa Iwanami (University of Tokushima) Medaka mutations affecting thymus organogenesis
10:15 - 10:30 Hisahiro Yoshida (RCAI RIKEN) Screen of immune disease model mice from ENU-induced mutant pool

Coffee

Thymic epithelial cells, Chair: Georg Hollnder

11:00 - 11:30 Clare Blackburn (University of Edinburgh) Thymic epithelial progenitor cells
11:30 - 12:00 Hans-Reimer Rodewald (University of Ulm) Insights into the role of the DiGeorge syndrome gene Tbx1 for thymus development from nude mouse blastocyst complementation
12:00 - 12:15 Shigeru Koshiba (Sapporo Medical University School of Medicine) p53-related transcription factors modulate intercellular connections of thymic medullary stromal cells through tight junctions
12:15 - 12:30 Ann Chidgey (Monash University) Reversal of thymic involution by sex steroid ablation: a molecular analysis

Epithelial-mesenchymal interactions for thymus development, Chair: Nancy Manley

14:30 - 15:00 Graham Anderson (University of Birmingham) Role of mesenchyme in thymus development and function
15:00 - 15:30 Ellen Richie (University of Texas) Thymus organogenesis in Pax3 sp/sp embryos
15:30 - 15:45 Hidetoshi Yamazaki (Tottori University) Neural crest-derived cells in the murine developing thymus and their potential for differentiation
15:45 - 16:00 Julie Gordon (University of Georgia) The role of BMP signaling in patterning the common thymus/parathyroid primordium

Coffee

Lympho-stromal interactions for thymus function, Chair: Bruno Kyewski

16:30 - 17:00 Willem van Ewijk (Leiden University) The Notch signalling pathway is involved in thymic crosstalk
17:00 - 17:30 Nancy Manley (University of Georgia) The Foxn1D/D thymic microenvironment supports T cell development from non-canonical progenitors
17:30 - 18:00 Manami Itoi (Meiji University of Oriental Medicine) The thymic perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma
18:00 - 18:15 Taishin Akiyama (University of Tokyo) TRAF6 in thymic stroma is essential for self-tolerance
18:15 - 18:30 Daniel Gray (Monash University) The relative contribution of thymic stromal cell subsets to negative selection
18:30 - 18:45 Mitsuru Matsumoto (University of Tokushima) Essential role of I_B kinase _lpha in thymic organogenesis required for the establishment of self-tolerance
18:45 - 19:00 William Jenkinson (University of Birmingham) Investigating the role of thymic mesenchyme in the regulation of thymocyte development

[INAMORI HALL]

Symposium on Immune Tolerance and Regulation, Chair: Kayo Inaba

9:00 - 9:30 Shimon Sakaguchi (Kyoto University) Control of immune responses by naturally occurring Foxp3-expressing CD25+CD4+ regulatory T cells
9:30 - 10:00 Ethan Shevach (NIH) Naturally occurring CD4+CD25+ regulatory T cells (nTR) function as a rapid response force to control effector T cell activation
10:00 - 10:30 Alexander Rudensky (University of Washington) Development of Foxp3-expressing Regulatory T cells

Coffee

Chair: Hitoshi Kikutani

11:00 - 11:30 Naoko Nakano (Tokyo University of Science) Homeostatic balance between nave and CD25+ regulatory T cells recognizing an altered peptide ligand expressed as a self-antigen
11:30 - 12:00 Miyuki Azuma (Tokyo Medial and Dental University) Dual functions of B7-H1 and B7-DC in immune responses
12:00 - 12:30 Lieping Chen (Johns Hopkins University School of Medicine) New co-signaling pathways in immune regulation

Chair: Miyuki Azuma

14:30 -15:00 Hitoshi Kikutani (Osaka University) Semaphorins in the Immune System
15:00 -15:30 Vijay Kuchroo (Harvard Medical School) TIM family of genes: role in T cell differentiation, autoimmunity and tolerance
15:30 -16:00 Kayo Inaba (Kyoto University) Plasmacytoid dendritic cells in human and mouse

Coffee

Chair: Shimon Sakaguchi

16:30 - 17:00 Pamela Ohashi (University of Toronto) Examining tolerance and immune surveillance
17:00 - 17:30 Sachiko Hirose (Juntendo Univeristy) Genetic aspect of aberrant activation of self-reactive B cells in systemic autoimmune disease
17:30 - 18:00 Kazuhiko Yamamoto (University of Tokyo) TCR gene transfer for controlling autoimmune diseases and immune-mediated disorders TCR gene transfer for controlling autoimmune diseases and immune-mediated disorders

April 8

Dynamics of developing thymocytes, Chair: Howard Petrie

9:00 - 9:30 Howard Petrie (Scripps Florida) T lineage commitment: extrathymic or intrathymic?
9:30 - 10:00 Conrad Bleul (Max-Planck-Institute for Immunobiology) A recent thymic immigrant maps to the branching point of the T versus B lineage decision
10:00 - 10:30 Yousuke Takahama (University of Tokushima) Cortex-medulla migration of thymocytes and central tolerance
10:30 - 11:00 Nikolaus Trede (University of Utah) In-vivo imaging in zebrafish &endash; a novel tool to tackle the genetics of autoimmunity

Coffee

T lymphopoiesis, Chair: Juan Carlos Ziga-Pflucker

11:30 - 12:00 Irving Goldschneider (University of Connecticut) Prothymocyte development is defective in IL-7Ra-/-, but not IL-7-/-, mice
12:00 - 12:15 Harumi Suzuki (Yamaguchi University) Effect of LIF on T-poiesis from multipoteintial Pax5 deficient pro-B cells
12:15 - 12:30 Shinya Ogawa (Kyoto University) Regulation of IL-7 receptor expression during T cell development
12:30 - 12:45 Shinji Fujimoto (Kyoto University) Forced Id2 expression generates NK cells from fully specified T cell precursors in murine fetal thymus
12:45 - 13:00 Yasutoshi Agata (Kyoto University) E2A proteins induce chromatin accessibility for V(D)J recombination through the alteration of histone modification

Early thymocyte development, Chair: Eric Jenkinson

15:00 - 15:30 Robson MacDonald (Ludwig Institute for Cancer Research) Role of Notch and pre-TCR signaling in T cell development and lineage commitment
15:30 - 16:00 Juan Carlos Zuniga-Pflucker (University of Toronto) The importance of Notch signals at the b-selectioncheckpoint
16:00 - 16:15 Masaki Miyazaki (Hiroshima University) Stability of Polycomb group protein influences intrathymic T cell development during DN to DP transition
16:15 - 16:30 Toshio Watanabe (Tohoku University) Forced expression of either one of two Runx1 isoforms exert differential effects on the thymocyte development

Coffee

Lineage determination to T cells, Chair: Hiroshi Kawamoto

17:00 - 17:30 Eric Jenkinson (University of Birmingham) T/B lineage choice occurs prior to intrathymic Notch signaling
17:30 - 17:45 Katsuto Hozumi (Tokai University) Pre-thymic Notch signaling is necessary for GATA3 to work in the earliest stage of T cell development
17:45 - 18:00 Arivazhagan Sambandam (University of Pennsylvania) Notch signaling controls the generation and differentiation of early T lineage progenitors
18:00 - 18:30 Hiroshi Kawamoto (RCAI RIKEN) Macrophage potential retained by early thymic T cell progenitors

18:30 -19:30 Posters with drink

P1 Michiyuki Kasai (NIID) A possible involvement of autophagy in presentation of cytoplasmic antigens via MHC class II molecules
P2 Junko Chiba (Nippon Veterinary and Animal Science University) Abnormal postnatal development of hypoplastic thymus in a new dwarf mutant rat strain PET
P3 Shizuko Kakinuma (NIRS) Cytokine production by thymic adherent cells during radiation-induced thymic lymphomagenesis
P4 Yi Shang (NIRS) Expression of cytokine receptors in radiation-induced mice thymic lymphoma
P5 Cunlan Liu (University of Tokushima) Differential roles of CCR7 and DOCK2 in cortex-medulla migration of positively selected thymocytes
P6 Hirofumi Shibata (Kyoto University) Regulation of IL-7 receptor expression by T cell receptor signal
P7 Atsushi Irie (Kumamoto University) PKD2, the major isoform of PKD family kinases expressed in the T cells and thymocytes, is involved in TCR-mediated T cell activation
P8 Jun Tsukada (RCAI RIKEN) Notch signals have a distinct role for nave and memory CD4 T cells
P9 Hirotake Tsukamoto (Kumamoto University) TCR ligand avidity determines the mode of B-RAF/MEK/ERK activation leading to proliferative response in human CD4+ T cells
P10 Ryoji Yagi (RCAI RIKEN) CNS-2 is key element for IL-4 production in initial IL-4 producer cells
P11 Shinya Hirata (Kumamoto University) Prevention of experimental autoimmune encephalomyelitis via induction of T cells with regulatory function by transfer of ES-DC expressing MOG peptide along with TRAIL

19:30 Getting together

April 9

Transcriptional regulation of T cell differentiation, Chair: Ellen Rothenberg

9:00 - 9:30 Ellen Rothenberg (California Institute of Technology) Transcription factor interplay in T lineage commitment
9:30 - 10:00 Takehito Sato (Tokai University School of Medicine) Dual functions of Runx proteins for re-activating CD8 and silencing CD4 at the commitment process into CD8 thymocytes
10:00 - 10:15 Kazuyoshi Kohu (Tohoku University) Over-expression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single positive lineage
10:15 - 10:30 Ichiro Taniuchi (RCAI RIKEN) Roles of Runx transcriptional factor complex during lymphocyte development

Coffee

T cell selection, Chair: Sonoko Habu

11:15 - 11:45 Sho Yamasaki (RCAI RIKEN) Molecular mechanism of pre-TCR-mediated signal transduction
11:45 - 12:15 Osami Kanagawa (RCAI RIKEN) The ability of individual thymocytes to generate multiple VJ alpha rearrangements is critical for normal T cell development
12:15 - 12:45 Alfred Singer (National Cancer Institute) Cytokine regulation of coreceptor expression: Implications for T cell selection and reactivity
12:45 - 13:00 Keiko Udaka (Kochi Medical School) Raft-associated presentation of MHC class II molecules guides thymocytes to the CD4 lineage

Signals regulating T cell development and responses, Chair: Takashi Saito

15:00 - 15:30 Michael Dustin (New York University) Patterns of tyrosine phosphorylation in the immunological synapse
15:30 - 16:00 Satoshi Matsuda (Keio University) Spry1 functions as a negative-feedback loop in the TCR signaling pathway
16:00 - 16:30 Rose Zamoyska (National Institute for Medical Research) Contrasting roles for p56lckand p59fyn in regulating nave T cell responses
16:30 - 16:45 Yoshinori Fukui (Kyushu University) DOCK2, a regulator of the actin cytoskeleton in lymphocytes, is anovel molecular target for controlling allo-graft rejection and autoimmune diseases
16:45 - 17:00 Hidehiro Kishimoto (Tokyo University of Science) Distinct function of NF-kB2-relB activation between semi-mature thymocytes and mature T cells

Coffee

T cell recognition and responses, Chair: Shigeo Koyasu

17:30 - 18:00 Joost van Meerwijk (INSERM) Molecular signature of recent thymic selection events on effector and regulatory CD4+ T lymphocytes
18:00 - 18:30 Leonore Herzenberg (Stanford University) Culturing lymphocytes at atmospheric oxygen levels impacts T cell function
18:30 - 18:40 Kazuko Shibuya (University of Tsukuba) Requirements of the serine at residue 329 for lipid rafts recruitment of DNAM-1 (CD226)
18:40 - 18:50 Shuhei Tomita (University of Tokushima) Hypoxia inducible factor-1a regulates in vivo T cell responses
18:50 - 19:00 Takamasa Ueno (Kumamoto University) Functionally impaired HIV-specific CD8 T cells show high-affinity TCR-ligand interactions
19:00 - 19:10 Sachiko Kondo (Toyama Medical and Pharmaceutical University) Detection of antigen-specific lymphocytes with microwell-array system
19:10 - 19:20 Yoshimasa Tanaka (Kyoto University) Analysis of mechanism for nonpeptide antigen recognition by human gd T cells
19:20 - 19:30 Satoru Senju (Kumamoto University) Therapeutic control of immune responses by genetically modified ES cell-derived dendritic cells

April 10

Signals regulating helper T-cell differentiation, Chair: Toshinori Nakayama

8:30 - 9:00 Mark Bix (University of Washington) Chromosome specific analysis of cis-acting DNA regulatory elements on Il4 locus
9:00 - 9:30 Masakatsu Yamashita (Chiba University) Ras-Erk MAPK cascade, GATA3, and the ubiquitin-proteasome pathway in Th2 differentiation
9:30 - 9:45 Shinsuke Taki (Shinshu University) Homeostatic regulation of the Th1/Th2 balance by controlling basophil population size
9:45 - 10:00 Motoko Kimura (Chiba University) Regulation of Th2 cell differentiation by murine schnurri-2
10:00 - 10:15 Masato Kubo (RCAI RIKEN) Regulation of initial IL-4 production in memory like Th2 cells by RBP-J/Notch signaling through conserved non-cording sequence (CNS)-2 on IL-4 locus

Coffee

T cell homeostasis and memory, Chair: Rose Zamoyska

10:45 - 11:15 Janko Nikolich-Zugich (Oregon Health & Science University) T-cell repertoire generation, diversity, maintenance and aging
11:15 - 11:30 Akemi Sakamoto (Chiba University) Bcl6 acts as an amplifier for the generation of central memory CD8 T cells
11:30 - 11:45 Shinya Tanaka (RCAI RIKEN) The physiological role of intrinsic memory-like T cells expressing IL-4 by primary antigen-stimulation
11:45 - 12:00 Hiroyuki Tezuka (Akita University) Impairment of APRIL-dependent IgA class-switch recombination in iNOS-/- mice
12:00 - 12:30 Elizabeth Simpson (Hammersmith Hospital) T cell responses to endogenous epitopes: balancing tolerance and immunity

Sandwich and coffee

Immune regulation and diseases, Chair:Nagahiro Minato

13:15 - 13:45 Shimon Sakaguchi (Kyoto University) Development of autoimmune arthritis due to a mutation of the ZAP-70 gene: T cell selection shift and altered Treg function
13:45 - 14:15 Bruno Kyewski (German Cancer Research Center) Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
14:15 - 14:45 Richard Boyd (Monash University) Restoration of thymic function and enhancement of haemopoiesis and lymphopoiesis following haemopoietic stem cell transplantation: re-shaping immunity for health
14:45 - 15:00 Wilfred Germeraad (University Hospital Maastricht) Tumour associated antigen mucin-1 is expressed on medullary epithelial cells in the thymus
15:00 - 15:15 Kenichiro Seino (Juntendo University) Immunoregulatory T cells and transplantation tolerance
15:15 - 15:45 Nagahiro Minato (Kyoto University) Chronic leukemia and systemic autoimmunity as hematopoietic stem cell disorders

Closing remarks

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