KTCC2009

5th International Workshop of Kyoto T Cell Conference

June 1-4, 2009 at Shiran Kaikan, Kyoto University

Organizers: Takashi Saito (chair), Manami Itoi-Watanabe, Hiroshi Kawamoto, Shigeo Koyasu, Nagahiro Minato, Toshinori Nakayama, Shimon Sakaguchi, Yousuke Takahama

Coorganized with the 3rd Symposium for the Mext Priority Research on Immunological Self -recognition and its disorders-

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Monday, June 1

15:00 − Registration

17:00 − 18:20 Keynote Lecture Chaired by Takashi Saito

THE IMPORTANCE OF TCR AFFINITY IN SELECTION AND RESPONSE
Michael Bevan

Tuesday, June 2

Session 1: Thymic microenvironments (1)

08:30 − 10:30 Chaired by Nancy Manley and Manami Itoi

PHYLOGENETIC AND ONTOGENETIC ASPECTS OF THYMUS DEVELOPMENT
Thomas Boehm

TROPICAL ISLANDS AND STARRY NIGHTS: DEVELOPING A BIOGEOGRAPHY OF THE THYMUS
Nancy Manley

CHARACTERIZATION OF FOXN1-POSITIVE CELLS IN THE POSTNATAL MOUSE THYMUS
Manami Itoi

REGULATION OF THYMIC EPITHELIAL CELL DEVELOPMENT
Graham Anderson

DICER IS REQUIRED FOR THE POSTNATAL MAINTENANCE OF THE THYMIC EPITHELIAL MICRO-ENVIRONMENT
Georg Hollander

DISRUPTING STEADY-STATE POSTNATAL MEDULLARY EPITHELIUM BY CONDITIONAL KNOCKOUT OF FOXN1 GENE TRIGGERS THYMIC INVOLUTION
Dong-Ming Su

THE ROLE OF HOXA3 DURING THE EARLY THYMUS ORGANOGENESIS
Kyoko Masuda

10:30 − 11:00 Coffee Break

Session 2: Lymphoid progenitors and lineage commitment (1)

11:00 − 12:40 Chaired by Graham Anderson and Hans-Reimer Rodewald

RETENTION AND TERMINATION OF MYELOID POTENTIAL IN T CELL PROGENITORS
Hiroshi Kawamoto

PROGENITORS WITH LYMPHOID AND MYELOID POTENTIAL SETTLE THE ADULT MOUSE THYMUS
Avinash Bhandoola

INTERLEUKIN 7 RECEPTOR-DRIVEN FATE MAPPING OF LYMPHOID PATHWAYS
Hans-Reimer Rodewald

NEW PERSPECTIVES ON THE T-LINEAGE COMMITMENT MECHANISM
Ellen Rothenberg

DEVELOPMENTAL POTENTIAL OF THE EARLIEST THYMIC MIGRANTS
Natalie Roberts

THYMIC PROGENITOR HOMING AND LYMPHOCYTE HOMEOSTASIS ARE LINKED VIA S1P CONTROLLED EXPRESSION OF THYMIC P-SELECTIN/CCL25
Klaus Gossens

Session 3: Lymphoid progenitors and lineage commitment (2)

14:20 − 15:50 Chaired by Howard Petrie and Hiroshi Kawamoto

NOTCH SIGNALING AND PRE-T CELL SURVIVAL AT THE β-SELECTION CHECKPOINT
Juan Carlos Zuniga-Pflucker

PRE-TCR SIGNALING INACTIVATES NOTCH1 TRANSCRIPTION BY ANTAGONIZING E2A SIGNALING AT THE β-SELECTION CHECKPOINT
Warren Pear

NOTCH AND LYMPHOCYTE DEVELOPMENT
Freddy Radtke

WHAT GOES UP MUST COME DOWN: THE CONSEQUENCES OF NOT TURNING DOWN PRE-TCR INDUCED BETA-CATENIN
Jyoti Sen

INDUCTION OF T CELL DEVELOPMENT BY THE IMMOBILIZED NOTCH LIGAND IN THE ABSENCE OF STROMAL CELLS
Tomokatsu Ikawa

CHARGED RESIDUES IN PRE-TCRa ARE CRITICAL FOR AUTONOMOUS β-SELECTION IN VIVO
Sho Yamasaki

15:50 − 16:20 Coffee Break

Session 4: Recognition and activation

16:20 − 18:30 Chaired by Naomi Taylor and Ed Palmer

CONTROL OF T CELL RECEPTOR EXPRESSION AND SIGNALLING OUTPUT ON PRE-SELECTION CD4+CD8+ THYMOCYTES
Bernard Malissen

DYNAMIC ASSEMBLY OF SIGNALING COMPLEX FOR POSITIVE AND NEGATIVE COSTIMULATION OF T CELL ACTIVATION
Takashi Saito

STIMULATION OF T CELL SUBSETS WITH CYTOKINE/ANTIBODY COMPLEXES
Jonathan Sprent

TCR SIGNALS MEDIATED BY THE SRC-FAMILY KINASES LCK AND FYN, AND THEIR ROLE IN THE DIFFERENTIATION OF T CELLS
Rose Zamoyska

DOWN-REGULATION OF RUNX1 EXPRESSION BY TCR SIGNAL IS MEDIATED IN AN AUTO-REGULATORY MECHANISM AND IS NECESSARY FOR MAXIMAL INTERLEUKIN-2 PRODUCTION
Masanobu Satake

EPIDERMAL γδT CELLS SENSE CELLULAR DYSREGULATION AND INNATE IMMUNE RESPONSES
Eri Shimura

GADS DELETION CONVERTS THE ab T-CELL LYMPHOPROLIFERATIVE DISORDER AFFLICTING LATY136F MICE INTO A LYMPHO-PROLIFERATIVE DISORDER INVOLVING γδ T-CELLS.
Herve Luche

TEMPORAL REGULATION OF THYMIC DEVELOPMENT ALLOWS SELECTION OF CD4 AND CD8 REPERTOIRES AT DIFFERENT SIGNALLING THRESHOLDS
Charles Sinclair

A NOVEL GENE ISC4 IS CRITICALLY REQUIRED FOR POSITIVE SELECTION OF THYMOCYTES
Harumi Suzuki

18:30 − 20:30 Poster Session

Wednesday, June 3

Session 5: Repertoire selection

08:30 − 10:20 Chaired by Rose Zamoyska and Stephen Jameson

HOW DOES THE TCR READ LIGAND AFFINITY?
Ed Palmer

FUNCTIONAL ADAPTATION OF THYMIC STROMAL CELLS FOR T CELL REPERTOIRE SELECTION
Ludger Klein

POSITIVE SELECTION BY THYMOPROTEASOME-EXPRESSING THYMIC EPITHELIAL CELLS SHAPES IMMUNOCOMPETENT REPERTOIRE OF CD8 T CELLS
Yousuke Takahama

INTRATHYMIC REGULATION OF GAMMA DELTA T CELL REPERTOIRE AND FUNCTION
Adrian Hayday

BASIS FOR SELECTION OF MHC-INDEPENDENT ab T CELLS IN THE THYMUS
Francois Van Laethem

CENTRAL TOLERANCE INDUCTION BY ADOPTIVE TRANSFER OF DONOR DENDRITIC CELLS
Hidehiro Kishimoto

THE EFFECT OF OVEREXPRESSION OF AN “IMMUNOPROTEASOME” SUBUNIT BETA5I IN CORTEICAL THYMIC EPITHELIAL CELLS
Yan Xing

10:20 − 10:50 Coffee Break

Session 6: Thymocyte differentiation

10:50 − 12:40 Chaired by Ichiro Taniuchi and Ellen Rothenberg

CD4 CORECEPTOR PROTEINS PROMOTE HELPER OR CYTOTOXIC LINEAGE FATES DEPENDING ONLY AND ENTIRELY ON THE CORECEPTOR GENE ENCODING THEM
Alfred Singer

TRANSCRIPTIONAL CONTROL OF CD4/CD8 LINEAGE CHOICE
Ichiro Taniuchi

A NOTCH FEEDBACK LOOP PROMOTES CD8 LINEAGE DIFFERENTIATION IN THE ABSENCE OF ZAP-70
Naomi Taylor

THE ZINC FINGER TRANSCRIPTION FACTOR Thpok REPRESSES CD8-LINEAGE GENE EXPRESSION IN PERIPHERAL CD4+ T CELLS
Remy Bosselut

EVIDENCE FOR THE COUPLING OF DNA REPLICATION CONTROL AND LINEAGE CHOICE INTO CD4/8 THYMOCYTES
Takehito Sato

FOXP1 IS AN ESSENTIAL TRANSCRIPTIONAL REGULATOR FOR THE GENERATION OF QUIESCENT T CELLS DURING THYMOCYTE DEVELOPMENT
Hui Hu

S1P1 IS SUFFICIENT TO ACCOUNT FOR THE ACQUISITION OF EGRESS COMPETENCE BY SINGLE-POSITIVE THYMOCYTES
Marcus Zachariah

14:00 − 15:00 Poster Session

Session 7: Thymic microenvironments (2)

15:00 − 16:50 Chaired by Eric Jenkinson and Yousuke Takahama

PROMISCUOUS GENE EXPRESSION IN THYMIC MEDULLARY EPITHELIAL CELLS: HOW IS THIS GENE POOL SELECTED?
Bruno Kyewski

EPIGENETIC MARKS DEFINE AIRE REGULATION OF TARGET GENES
Part Peterson

AIRE-DEPENDENT ORGANIZATION OF THYMIC MICROENVIRONMENT
Mitsuru Matsumoto

AIRE AND THYMIC EPITHELIAL CELL DEATH
Daniel Gray

ONTOGENY AND REGULATION OF PROMISCUOUS GENE EXPRESSION: A STUDY OF THE CASEIN GENE LOCUS
Jens Derbinski

DIRECT ANTIGEN PRESENTATION BY MEDULLARY THYMIC EPITHELIAL CELLS IS ESSENTIAL FOR CD4 T CELL TOLERANCE
Maria Hinterberger

SELF-ANTIGEN EXPRESSION IN EXTRATHYMIC AIRE-EXPRESING CELLS PREVENTS ANTIGEN-SPECIFIC AUTOIMMUNITY
James Gardner

16:50 − 17:20 Coffee Break

Session 8: Thymic microenvironments (3)

17:20 − 19:10 Chaired by Willem van Ewijk and Ann Chidgey

IMMUNOLOGICAL IMPRINT OF TOLERANCE IMPARTED BY THE AUTOIMMUNE REGULATOR
Mark Anderson

HETEROGENEITY OF EPITHELIAL CELLS EXPRESSING TISSUE-RESTRICTED ANTIGENS IN THE THYMUS
Andrew Farr

COMPARATIVE IMMUNOMODULATING PROPERTIES OF MESENCHYMAL STROMAL CELLS AND AMNION EPITHELIAL STEM CELLS
Richard Boyd

EPITHIN ON THE THYMIC EPITHELIAL CELL REGULATES ANGIOPOIETIN RECEPTOR TIE2 ON THE ENDOTHELIAL CELL
Moon Kim

DISTRIBUTION AND FUNCTION OF IL-7-PRODUCING STROMAL CELLS
Koichi Ikuta

ANALYSIS OF THYMIC MEDULLARY EPITHELIAL CELL SUBPOPULATIONS
Tomoo Ueno

MMP-19 AND THYMIC CONDUITS
Paulina Rymkiewicz

IDENTIFYING THE MOLECLAR FACTORS RESPONSIBLE FOR REGULATING DELTA-LIKE 4 EXPRESSION ON THYMIC STROMA
Korosh Kianizad

19:30 − 21:30 Mixer

Thursday, June 4

Session 9: Immune response and memory (1)

08:30 − 10:30 Chaired by Jonathan Sprent and Janko Nikolich-Zugich

SOURCE AND ROLE OF ENDOGENOUS ANTIGEN-SPECIFIC MEMORY CD8 T CELLS IN UNPRIMED MICE
Stephen Jameson

T FOLLICULAR HELPER CELLS AND THE REGULATION OF ANTIBODY RESPONSES
Charles Mackay

“NATURAL HELPER CELL” IN THE MESENTERY
Shigeo Koyasu

REGULATION OF T HELPER CELL LINEAGE DEVELOPMENT BY OSTEOPONTIN
Mari Shinohara

FALLOUT FROM THYMIC CATASTROPHY IN ADVANCED AGE − FUNCTIONAL AND HOMEOSTATIC ASPECTS
Janko Nikolich-Zugich

PROFESSIONAL MEMORY CD4+ T LYMPHOCYTES RESIDE AND REST IN THE BONE MARROW
Koji Tokoyoda

IDENTIFICATION OF CD25+ γδ T CELLS AS FETAL THYMUS-DERIVED NATURALLY OCCURRING IL-17 PRODUCERS
Kensuke Shibata

10:30 − 11:00 Coffee Break

Session 10: Immune response and memory (2)

11:00 − 12:30 Chaired by Toshinori Nakayama and Charlie Surh

REGULATION OF MEMORY TH CELL SURVIVAL AND FUNCTION BY THE POLYCOMB AND TRITHORAX GROUP GENE PRODUCTS
Toshinori Nakayama

MECHANISMS BEHIND POTENT ACTIVITY OF CYTOKINE/mAB COMPLEXES
Charles Surh

MOLECULAR DETERMINANTS OF CD8+ T CELL MEMORY
Stephen Schoenberger

RUNX/CBF-B IS A CRITICAL GATEKEEPER THAT DIRECTS THE TH1 AND TH17 DIFFERENTIATION
Masato Kubo

GATA3 PREVENTS TH2 CELL IFN-GAMMA PRODUCTION BY REPRESSING EOMESODERMIN EXPRESSION
Ryoji Yagi

Session 11: Immune regulation and diseases (1)

14:10 − 15:30 Chaired by Shigeo Koyasu and Fumihiko Ishikawa

A UNIQUE T CELL POPULATION UNDERLYING ALTERED IMMUNE TRAITS IN SENESCENCE AND MALIGNANCY
Nagahiro Minato

RECONSTITUTION OF HUMAN IMMUNE SYSTEM IN MICE
Fumihiko Ishikawa

PD-1 REGULATES IL-2 PRODUCTION, WHICH INDUCES CD8+ T CELL ANERGY
Shunsuke Chikuma

CCR7-DEPENDENT S1P1 AND AP-1 SIGNALING IS ESSENTIAL FOR CD4+CD25+FOXP3+ REGULATORY T CELL FUNCTION IN VIVO
Naozumi Ishimaru

LIVER AS A REGULATOR OF T CELLS
Masaaki Murakami

A CELL AUTONOMOUS REQUIREMENT FOR TRAF6 IN THE DEVELOPMENT OF NATURALLY OCCURING REGULATORY T CELLS
Yusuke Shimo

15:30 − 16:00 Coffee Break

Session 12: Immune regulation and diseases (1)

16:00 − 17:00 Chaired by Shimon Sakaguchi and Nagahiro Minato

TRANSCRIPTIONAL REGULATION IN CD4+CD25+ REGULATORY T CELLS
Masahide Tone

T-BET CONTROLS REGULATORY T CELL HOMEOSTASIS AND FUNCTION DURING TYPE-1 INFLAMMATION
Daniel Campbell

T CELL SIGNALING, REGULATORY T CELLS, AND SELF-TOLERANCE
Shimon Sakaguchi

Closing Remarks

Posters

P-001.
INTRACLONAL COMPETITION LIMITS REGULATORY T CELL FATE DETERMINATION IN THE THYMUS
Jhoanne L. Bautista

P-002.
FOXN1 IS REQUIRED FOR THYMIC VASCULARIZATION
Jerrod L Bryson

P-003.
SEARCHING FOR RESIDENT EPITHELIAL STEM CELLS IN THE ADULT THYMUS
Ann Chidgey

P-004 = O-73.
PD-1 REGULATES IL-2 PRODUCTION, WHICH INDUCES CD8+ T CELL ANERGY
Shunsuke Chikuma

P-005 = O-48.
ONTOGENY AND REGULATION OF PROMISCUOUS GENE EXPRESSION: A STUDY OF THE CASEIN GENE LOCUS
Jens Derbinski

P-006.
ENGINEERED IN VIVO NICHES TO TRAP, MAINTAIN AND SPECIFY MOUSE LYMPHOCYTE PROGENITORS
Lesly Calderon Dominguez

P-007.
THE RhoA EFFECTER mDia1 REGULATE MOTILITY AND FUNCTION IN T LYMPHOCYTES
Gyohei Egawa

P-008.
AN EXAMPLE OF NEGATIVE SELECTION DURING THYMIC LYMPHOMAGENESIS
Shinji Fujimoto

P-009 = O-50.
SELF-ANTIGEN EXPRESSION IN EXTRATHYMIC AIRE-EXPRESING CELLS PREVENTS ANTIGEN-SPECIFIC AUTOIMMUNITY
James Gardner

P-010.
PSGL-1 EXPRESSED CD4 T CELLS IN CULPRIT CORONARY ARTERY OF ACUTE CORONARY SYNDROME
Keiko Gomita

P-011 = O-14.
THYMIC PROGENITOR HOMING AND LYMPHOCYTE HOMEOSTASIS ARE LINKED VIA S1P CONTROLLED EXPRESSION OF THYMIC P-SELECTIN/CCL25
Klaus Gossens

P-012.
THE FUNCTION OF BMI-1 IN THE THYMIC EPITHELIAL CELLS
Yun Guo

P-013.
CLAUDIN EXPRESSION IN THYMOCYTES: IMPLICATION IN T CELL DEVELOPMENT
Yoko Hamazaki

P-014.
A NOVEL MOUSE MODEL OF PBC-LIKE AUTOIMMUNE CHOLANGITIS AND MULTIFOCAL EPITHELIAL INFLAMMATIONS TRIGGERED BY BACTERIAL EXPOSURE
Ikuko Haruta

P-015.
TCR MICROCLUSTERS MOVE ALONG MICROTUBLES IN EARLY T CELL ACTIVATION
Akiko Hashimoto-Tane

P-016.
REGULATION OF TCRb REARRANGEMENT AND EXPRESSION BY CD28
KS Hathcock

P-017.
GENERATION OF THE THIRD PHARYNGEAL POUCH-RELATED CELLS FROM MOUSE EMBRYONIC STEM CELLS
Kyoko Hidaka

P-018 = O-49.
DIRECT ANTIGEN PRESENTATION BY MEDULLARY THYMIC EPITHELIAL CELLS IS ESSENTIAL FOR CD4 T CELL TOLERANCE
Maria Hinterberger

P-019.
MEIS1 DEFICIENCY IMPAIRS THE POSTNATAL THYMIC MICROENVIRONMENT TO INDUCE EARLY THYMIC INVOLUTION
Takehiro Hirayama

P-020.
DOSE-DEPENDENT EFFECT OF ZINC-FINGER TRANSCRIPTIONAL FACTOR Rit1/Bcl11b ON DIFFERENTIATION OF CYTOTOXIC T CELLS
Satoshi Hirose

P-021.
DLL4 IS INDISPENSABLE FOR THE DIFFERENTIATION OF DN TO DP STAGES IN THE THYMUS
Katsuto Hozumi

P-022 = O-42.
FOXP1 IS AN ESSENTIAL TRANSCRIPTIONAL REGULATOR FOR THE GENERATION OF QUIESCENT T CELLS DURING THYMOCYTE DEVELOPMENT
Hui Hu

P-023 = O-19.
INDUCTION OF T CELL DEVELOPMENT BY THE IMMOBILIZED NOTCH LIGAND IN THE ABSENCE OF STROMAL CELLS
Tomokatsu Ikawa

P-024 = O-55.
DISTRIBUTION AND FUNCTION OF IL-7-PRODUCING STROMAL CELLS
Koichi Ikuta

P-025 = O-74.
CCR7-DEPENDENT S1P1 AND AP-1 SIGNALING IS ESSENTIAL FOR CD4+CD25+FOXP3+ REGULATORY T CELL FUNCTION IN VIVO
Naozumi Ishimaru

P-026.
ENU-MUTAGENESIS IN ZEBRAFISH IDENTIFIES A SPECIFIC REQUIREMENT FOR LSM8 IN THYMUS DEVELOPMENT
Norimasa Iwanami

P-027.
AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN Mlh1-DEFICIENT MICE
Shizuko Kakinuma

P-028.
MACROAUTOPHAGY INTERCROSS TO MHC CLASS II-ANTIGEN PRESENTATION IN THYMIC EPITHELIAL CELLS
Michiyuki Kasai

P-029 = O-58.
IDENTIFYING THE MOLECLAR FACTORS RESPONSIBLE FOR REGULATING DELTA-LIKE 4 EXPRESSION ON THYMIC STROMA
Korosh Kianizad

P-030 = O-54.
EPITHIN ON THE THYMIC EPITHELIAL CELL REGULATES ANGIOPOIETIN RECEPTOR TIE2 ON THE ENDOTHELIAL CELL
Moon Gyo Kim

P-031.
POLARITY PROTEINS IN ASYMMETRIC CELL DIVISION DURING THYMOCYTE DEVELOPMENT
Pham Kim

P-032.
BASIS FOR IL-7’S FUNCTION AS A HOMEOSTATIC CYTOKINE
Motoko Y. Kimura

P-033 = O-35.
CENTRAL TOLERANCE INDUCTION BY ADOPTIVE TRANSFER OF DONOR DENDRITIC CELLS
Kishimoto, H.

P-034.
INCREASES IN THE PERCENTAGES OF CD43-LOW MEMORY AND CD25+/CD127- REGULATORY T CELLS IN THE CD4 T-CELL POPULATIONS AMONG A-BOMB SURVIVORS
Yoichiro Kusunoki

P-035.
RARE DEVELOPMENT OF FOXP3+ THYMOCYTES IN THE CD4+CD8+ SUBSET
Hyang-Mi Lee

P-036.
DEFECTIVE ENTERIC TOLERANCE IN CHRONICALLY LYMPHOPENIC MICE IS NOT TRIGGERED BY ENTERIC BACTERIA, BUT BY ABSENCE OF T CELL REPERTOIRES
Joon Youb Lee

P-037.
MEMORY-LIKE CD8+ T CELLS REQUIRE ANTIGEN-SPECIFIC CD4 HELP TO INDUCE AUTOIMMUNITY UNDER LYMPHOPENIC CONDITIONS
Cecile Le Saout

P-038 = O-27.
GADS DELETION CONVERTS THE αβ T-CELL LYMPHOPROLIFERATIVE DISORDER AFFLICTING LATY136F MICE INTO A LYMPHO-PROLIFERATIVE DISORDER INVOLVING γδ T-CELLS.
Herve LUCHE

P-039.
ELUCIDATING REGULATORY T CELLS TCR SPECIFICITY AND REPERTOIRE: A NEW MOUSE MODEL
Maria Encarnita Mariotti-Ferrandiz

P-040 = O-08.
THE ROLE OF HOXA3 DURING THE EARLY THYMUS ORGANOGENESIS
Kyoko Masuda

P-041.
THYMOCYTE- AND THYMIC-MEDULLA-INDEPENDENT EXPRESSION OF THYMOPROTEASOME β5t IN THYMIC CORTICAL EPITHELIAL CELLS
Adiratna Mat Ripen

P-042.
LMO2-ASSOCIATED T-CELL LYMPHOBLASTIC LEUKAEMIA IS INITIATED THROUGH THYMOCYTE SELF-RENEWAL
Matthew P. McCormack

P-043.
ADOPTIVE T/NK CELL PROGENITOR THERAPY FOR PATIENTS UNDERGOING HSC-TRANSPLANTATION
B Meek

P-044 = O-61.
“NATURAL HELPER CELL” IN THE MESENTERY
Kazuyo Moro

P-045 = O-75.
LIVER AS A REGULATOR OF T CELLS
Masaaki Murakami

P-046.
SUBVERSION OF PKCALPHA CAUSES LINEAGE PLASTICITY ON PRO-B CELLS
Rinako Nakagawa

P-047.
INITIATION OF INFLAMMATORY SKIN RESPONSES BY PROMOTING TH DIFFERENTIATION THROUGH PROSTAGLANDIN I RECEPTOR IP
Saeko Nakajima

P-048.
A POSSIBLE DEVELOPMENTAL PATHWAY OF FOXP3+ REGULATORY T CELLS IN THE THYMUS
Naoko Nakano

P-049.
CONTROL MECHANISMS IN MATURE T CELL LEUKEMIA/LYMPHOMA
Sebastian Newrzela

P-050.
MOLECULAR MECHANISM CONTROLLING INTRACELLULAR DOCK2 DYNAMICS DURING NEUTROPHIL CHEMOTAXIS
Akihiko Nishikimi

P-051.
REVISITING THYMIC NURSE CELLS
Takeshi Nitta

P-052.
THE TYROSINE PHOSPHORYLATION OF CD28 AND CD28 MEDIATED COSTIMULATION
Shuhei Ogawa

P-053.
THE FUNCTION OF SEC8 MOLECULES, A SUBUNIT OF EXOCYST COMPLEX, IN INFLAMMATORY CELLS.
Misuzu Okada

P-054.
CYTOKINE SIGNALING INDUCES RUNX3 AND SPECIFIES CD8 LINEAGE CHOICE DURING CD4/CD8 CELL FATE DECISION IN THE THYMUS
Jung-Hyun Park

P-055.
ANTIBODY-MEDIATED BLOCKADE OF IL-15 REVERSES THE AUTOIMMUNE INTESTINAL DAMAGE IN TRANSGENIC MICE THAT OVEREXPRESS IL-15 IN ENTEROCYTES
Liyanage P. Perera

P-056 = O-13.
DEVELOPMENTAL POTENTIAL OF THE EARLIEST THYMIC MIGRANTS
Natalie A Roberts

P-057 = O-57.
MMP-19 AND THYMIC CONDUITS
Paulina Rymkiewicz

P-058 = O-25.
DOWN-REGULATION OF RUNX1 EXPRESSION BY TCR SIGNAL IS MEDIATED IN AN AUTO-REGULATORY MECHANISM AND IS NECESSARY FOR MAXIMAL INTERLEUKIN-2 PRODUCTION
Masanobu Satake

P-059 = O-41.
EVIDENCE FOR THE COUPLING OF DNA REPLICATION CONTROL AND LINEAGE CHOICE INTO CD4/8 THYMOCYTES
Takehito Sato

P-060.
THE FUNCTION OF CD69 MOLECULES ON DENDRITIC CELLS TO INDUCE IL-17 PRODUCING CELLS
Keiko Sawada

P-061 = O-18.
WHAT GOES UP MUST COME DOWN: THE CONSEQUENCES OF NOT TURNING DOWN PRE-TCR INDUCED BETA-CATENIN
Jyoti Misra Sen

P-062.
TRANSCRIPTIONAL REGULATION OF Il9r IN RADIATION-INDUCED MOUSE T-CELL LYMPHOMA CELL LINE
Yi Shang

P-063 =O-65.
IDENTIFICATION OF CD25+ γδ T CELLS AS FETAL THYMUS-DERIVED NATURALLY OCCURRING IL-17 PRODUCERS
Kensuke Shibata

P-064.
ACCELERATED TUMOR GROWTH IN MICE DEFICIENT IN DNAM-1 RECEPTOR
Kazuko Shibuya

P-065 = O-76.
A CELL AUTONOMOUS REQUIREMENT FOR TRAF6 IN THE DEVELOPMENT OF NATURALLY OCCURING REGULATORY T CELLS
Yusuke Shimo

P-066 = O-26.
EPIDERMAL γδT CELLS SENSE CELLULAR DYSREGULATION AND INNATE IMMUNE RESPONSES
Eri Shimura

P-067 = O-28.
TEMPORAL REGULATION OF THYMIC DEVELOPMENT ALLOWS SELECTION OF CD4 AND CD8 REPERTOIRES AT DIFFERENT SIGNALLING THRESHOLDS
Charles Sinclair

P-068.
RETINOIC ACID AND THYMOCYTE DEVELOPMENT
Katarzyna Sitnik

P-069.
AGING INCREASES SUSCEPTIBILITY TO SYSTEMIC INFECTION WITH L. MONOCYTOGENES VIA T-CELL DEFECTS
Megan J. Smithey

P-070 =O-07.
DISRUPTING STEADY-STATE POSTNATAL MEDULLARY EPITHELIUM BY CONDITIONAL KNOCKOUT OF FOXN1 GENE TRIGGERS THYMIC INVOLUTION
Dong-Ming Su

P-071.
THE ROLE OF CENTRAL TOLERANCE IN MEDIATING AUTOIMMUNE PERIPHERAL NEUROPATHY
Maureen A. Su

P-072 = O-29.
A NOVEL GENE ISC4 IS CRITICALLY REQUIRED FOR POSITIVE SELECTION OF THYMOCYTES
Harumi Suzuki

P-073.
FUNCTIONALITY OF REGULATORY T CELLS REQUIRE PERSISTENT IN VIVO COSTIMULATION TO MAINTAIN CTLA-4 EXPRESSION
Xuguang Tai

P-074.
SELF MHC CLASS I SUPPORTS SURVIVAL OF NAI¨VE CD8+ T CELLS BUT DEPRESS THEIR SENSITIVITY THROUGH DOWNREGULATION OF CD8 LEVELS
Kensuke Takada

P-075.
GENETIC EVIDENCE FOR DISTINCT REGULATION OF ThPOK SILENCER AT DIFFERENT STAGES OF THYMOCYTE DEVELOPMENT
Hirokazu Tanaka

P-076 = O-64.
PROFESSIONAL MEMORY CD4+ T LYMPHOCYTES RESIDE AND REST IN THE BONE MARROW
Koji Tokoyoda

P-077.
CHARACTERIZATION OF REGULATORY T CELLS MIGRATED FROM SKIN TO DRAINING LYMPH NODE USING KAEDE-TRANSGENIC MICE
Michio Tomura

P-078.
SELF-ASSEMBLED CATIONIC NANOGEL-MEDIATED EFFICIENT PROTEIN DELIVERY IN MOUSE PRIMARY T CELLS
Takeshi Tsubata

P-079.
INDUCTION OF TH1-TYPE IMMUNE RESPONSE THROUGH IFN-b BY LACTIC ACID BACTERIA
Noriko M Tsuji

P-080.
COMPARATIVE ANALYSIS OF LYMPHOCYTES FROM MOUSE STRAINS WITH DIFFERING SUSCEPTIBILITY TO EXPERIMENTAL ASTHMA
Damon J Tumes

P-081 = O-56.
ANALYSIS OF THYMIC MEDULLARY EPITHELIAL CELL SUBPOPULATIONS
Tomoo Ueno

P-082.
THE THYMUS.....FOLLOW ME!
Willem van Ewijk

P-083 = O-34.
BASIS FOR SELECTION OF MHC-INDEPENDENT αβ T CELLS IN THE THYMUS
Francois Van Laethem

P-084.
INTRATHYMIC TRANSPLANTATION OF BONE MARROW DERIVED PROGENITORS PROVIDES LONG-TERM THYMOPOIESIS
Rita Vicente

P-085.
THYMIC CYSTS ORIGINATE FROM FOXN1 POSITIVE THYMIC MEDULLARY EPITHELIUM
Eric Vroegindeweij

P-086.
GENERATION OF FUNCTIONAL T CELLS FROM ES CELLS AND INDUCED PLURIPOTENT STEM (IPS) CELLS IN VITRO
Haruka Wada

P-087.
FORCED EXPRESSION OF FILAMIN A MAY DECREASE DOUBLE POSITIVE THYMOCYTES DURING THYMOCYTE DEVELOPMENT
Toshio Watanabe

P-088 = O-36.
THE EFFECT OF OVEREXPRESSION OF AN “IMMUNOPROTEASOME” SUBUNIT BETA5I IN CORTEICAL THYMIC EPITHELIAL CELLS
Yan Xing

P-089 = O-70.
GATA3 PREVENTS TH2 CELL IFN-GAMMA PRODUCTION BY REPRESSING EOMESODERMIN EXPRESSION
Ryoji Yagi

P-090.
INDUCTION OF PRO-APOTOTIC SIGNALS VIA THE CD28 IN THE THYMUS
Yamano, T.

P-091 = O-20.
CHARGED RESIDUES IN PRE-TCRα ARE CRITICAL FOR AUTONOMOUS β-SELECTION IN VIVO
Sho Yamasaki

P-092.
IL-4 AND IL-21 INVERSELY REGULATE CXCR4 EXPRESSION ON ACTIVATED B CELLS
Nobuya Yoshida

P-093.
MICRORNA-MEDIATED REGULATION OF T CELL TOLERANCE AND DIFFERENTIATION
Di Yu

P-094 = O-43.
S1P1 IS SUFFICIENT TO ACCOUNT FOR THE ACQUISITION OF EGRESS COMPETENCE BY SINGLE-POSITIVE THYMOCYTES
Marcus A. Zachariah

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Last update; July 7, 2009