6th International Workshop of Kyoto T Cell Conference (KTCC2013) Click HERE to download the poster

Venue: Shiran Kaikan, Kyoto University, Kyoto 606-8501, Japan

Date: 3 -7 June 2013

Organizing committee: Shigeo Koyasu (chair), Manami Itoi, Hiroshi Kawamoto, Toshinori Nakayama, Takehito Sato, Ichiro Taniuchi, and Yousuke Takahama (secretary general)

Coorganized with First International Symposium for MEXT Scientific Research on Analysis and Synthesis of Multidimentional Immune Organ Network

Snap shots at the meeting can be found HERE and the group picture can be downloaded HERE


Monday 3 June

15:00 Registration open at Shiran Kaikan

Keynote lectures (chaired by Shigeo Koyasu)

17:00 – 17:05 Opening remarks by Shigeo Koyasu

17:05 – 17:50 Alfred Singer
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire

17:50 – 18:35 Ellis Reinherz
DP thymocyte integrin nanoclusters, catch bonds and plexinD1: intrathymic adhesion control impacts selection

18:35 – 19:20 Shimon Sakaguchi
Genetic and epigenetic control of regulatory T cell development

20:00 Welcome drink at Kyoto Hotel Okura

Tuesday 4 June

Session 1. T cell progenitors (chaired by Hiroshi Kawamoto and Wilfred Germeraad)

09:00 – 09:20 Sten Eirik Jacobsen
Emergence of immune-restricted lympho-myeloid progenitors prior to definitive hematopoietic stem cells

09:20 – 09:40 Hans-Reimer Rodewald
Progenitor flow to the thymus, progenitor turnover and T cell leukemia

09:40 – 10:00 Wilfred Germeraad
A feeder free culture differentiates human CD34+ HSC to CD4+CD8+ T cells

10:00 – 10:10 Kazuaki Yokoyama
In vivo oncogenicity of activating mutant of IL-7 alpha chain highlight the distinct role of signaling vs lineage determining factors

10:10 – 10:30 Akihiko Yoshimura
The nuclear orphan receptor Nr4a family is essential for nTreg development and immune homeostasis


Session 2. T cell lineage determination (chaired by JC Zúñiga-Pflücker and Katia Georgopoulos)

11:00 – 11:20 Katia Georgopoulos
Harnessing chromatin remodeling for lymphocyte differentiation

11:20 – 11:40 Hiroshi Kawamoto
Molecular mechanisms for production and maintenance of the T cell lineage

11:40 – 12:00 Juan Carlos Zúñiga-Pflücker
Initiation of the T-lineage development program in response to Notch signals requires GATA-3 for survival and full commitment of early progenitors

12:00 – 12:10 Tomokatsu Ikawa
A genetic network during the T cell lineage specification

12:10 – 12:20 Farbod Famili
TCF-1 functions as an essential gatekeeper of T cell identity in the thymus

12:20 – 12:30 Shoichiro Miyatake
BTB-ZF transcription factor ZNF131 is crucial for early T cell development in thymus and exerts its function through the interaction with GATA3

12:30 – 12:40 Michele Anderson
HEB factors are required for functional programming of fetal γδ T cell subsets

Lunch (business meeting for KTCC members)

Session 3. Thymus organogenesis (chaired by Manami Itoi and Nancy Manley)

14:00 – 14:20 Thomas Boehm
Phylogenetic aspects of thymopoiesis

14:20 – 14:40 Nancy Manley
Complex tissue specific roles for HOXA3 during thymus organogenesis

14:40 – 15:00 Ellen Richie
Tbx1 and Shh regulate thymus vs parathyroid domain patterning of 3rd pp endoderm

15:00 – 15:10 Joachim R. Göthert
Mice with thymic epithelial von Hippel-Lindau deletion are lacking a functional thymus

15:10 – 15:20 Olga Ucar
Identification of a putative epithelial stem cell from adult mouse thymus

15:20 – 15:30 Kahlia Wong
Characterising putative thymic epithelial progenitor cells in the adult murine thymus

15:30 – 15:40 Caroline Berkemeier
The Role of mTOR for the development and function of the mouse thymic epithelium


Session 4. Thymus compartmentalization (chaired by Yoko Hamazaki and Graham Anderson)

16:10 – 16:30 Yousuke Takahama
Development and developmental potential of β5t-expressing thymic epithelial cells

16:30 – 16:50 Yoko Hamazaki
Medullary thymic epithelial stem cells ensuring lifelong central T-cell tolerance

16:50 – 17:10 Graham Anderson
Development and function of the thymic medulla

17:10 – 17:30 Manami Itoi
Generation of RANK positive thymic medullary epithelial progenitors does not require interaction with developing thymocytes

17:30 – 17:50 Magali Irla
Role of autoreactive CD4+ thymocytes in the thymic medulla patterning and homeostasis

17:50 – 18:00 Taishin Akiyama
Requirement of RANKL signaling for maintenance of mature mTECs in adult thymus

18:00 – 18:10 Takeshi Nitta
Novel mutant mice lacking cortical thymic epithelial cells

18:10 – 18:20 Katsuto Hozumi
Establishment of Dll1/4 conditional Tg mice by the recombinase-mediated cassette exchange (RMCE)

18:20 – 18:30 Laura Simons
Combinatorial expression of Il-7, DLL4 and SDF-1 is sufficient for reconstitution of the γδ T cell lineage in Foxn1-deficient embryonic thymus

18:30 – 19:30 Poster session #1

19:30 Mixer at Shiran Kaikan

Wednesday 5 June

Session 5. Thymic medulla and self-tolerance (chaired by Georg Hollander and Ann Chidgey)

09:00 – 09:20 Georg Holländer
Transcriptome and functional analyses of individual thymic epithelial cell populations

09:20 – 09:40 Pärt Peterson
AIRE-PHD zinc fingers as structural domains for chromatin associated interactions

09:40 – 10:00 Matthieu Giraud
An RNAi screen for Aire cofactors: Aire identifies stalled polymerases and cooperates with Hnrnpl to promote ectopic gene expression

10:00 – 10:20 Mitsuru Matsumoto
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program

10:20 – 10:30 Jakub Abramson
Runx3 and Runx1 – the agonist and antagonist of Aire-driven gene expression in medullary thymic epithelial cells

10:30 – 10:40 Sheena Pinto
Lack of epitope in the thymus and biased TCR usage correlate with high frequency of peripheral MART-1-specific T cells


Session 6. Thymic repertoire formation (chaired by Yousuke Takahama and Ludger Klein)

11:00 – 11:20 Richard Boyd
Thymus rejuvenation - teaching an old dog new tricks for tolerance induction

11:20 – 11:40 Ludger Klein
Macroautophagy in thymic epithelium and central CD4 T cell tolerance

11:40 – 12:00 Sylvie Guerder
Thymus specific serine protease, a novel protease that shapes the peptide repertoire presented by MHC class II molecules in the thymus

12:00 – 12:10 Kensuke Takada
Functional conditioning of CD8 T cells by thymoproteasome-dependent positive selection

12:10 – 12:20 Jennifer Cowan
Dynamic changes in chemokine receptor expression reveals multiple checkpoints in the intrathymic positive selection of CD4+ T-cells

12:20 – 12:30 Maria Mouchess
Exploring the role of Aire-expressing cells in shaping the thymic Treg repertoire

12:30 – 12:40 Lauren Ehrlich
Contributions of the thymic microenvironment to T cell acute lymphoblastic leukemia/lymphoma

Lunch (group photograph)

Session 7. Thymocyte development (chaired by Ichiro Taniuchi and Ellen Rothenberg)

14:00 – 14:20 Ellen Rothenberg
Distinct dose-dependent roles for GATA-3 in gene regulatory networks controlling early T-cell lineage commitment

14:20 – 14:40 Paul Love
New insights into the role of TCR-ITAM-mediated signal amplification in T cell development and for T cell effector responses

14:40 – 15:00 Takehito Sato
ThPOK/Runx3-mediated CD4/8 thymocyte cell fate decision is reciprocally controlled by G1-S cell cycle progression

15:00 – 15:20 Ichiro Taniuchi
Local chromatin loops at the Thpok locus regulate CD4/CD8 lineage choice

15:20 – 15:30 Wilfried Ellmeier
CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

15:30 – 15:40 Rémy Bosselut
Role of histone demethylases Jmjd3 and Utx in late T cell development

15:40 – 15:50 Motoko Kimura
Effect on lineage fate of prolonging TCR signal duration during MHC-I specific positive selection

15:50 – 16:00 Harumi Suzuki
Differential function of Themis CABIT domains during T cell development

16:00 – 16:10 Eri Ishikawa
Protein kinase D is a critical component for T cell development


Session 8. Regulatory T cell development (chaired by Ming Li and Shohei Hori)

16:30 – 16:50 Chyi-Song Hsieh
Direct relationship between self-reactivity and thymic regulatory T cell development
16:50 – 17:10 Juan Lafaille
Thymic and peripheral Foxp3+ regulatory T cells

17:10 – 17:30 Ming Li
TGF-β control of T cell development and homeostasis

17:30 – 17:50 Daniel Gray
The apoptotic mechanisms that drive regulatory T cell genesis and homeostasis

17:50 – 18:00 Ryuichi Murakami
Genetic control of Foxp3+ regulatory T cell fitness in peripheral tissues


Session 9. T cell dynamics (chaired by Yoshinori Fukui and Masayuki Miyasaka)

18:20 – 18:40 Reinhold Forster
Lymph node homing of immune cells via afferent lymphatics

18:40 – 19:00 Yoshinori Fukui
Regulation of leukocyte trafficking and T-cell immune response by DOCK family proteins

19:00 – 19:20 Masayuki Miyasaka
The ATX/LPA axis is a novel regulator of lymphocyte extravasation across HEVs

19:20 – 19:40 Alexander Flügel
How effector T cells enter the nervous tissue and initiate autoimmune CNS disease

19:40 – 19:50 Naoko Nakano
Occludin is involved in the motility of epidermal γδ T cells

19:50 – 20:00 Roland Scollay
How long do developing thymocytes really spend in the thymic medulla?

20:00 – 21:30 Poster session #2 (with drinks and snacks)

Thursday 6 June

Session 10. T cell recognition and activation (chaired by Naomi Taylor and Mitchell Kronenberg)

09:00 – 09:20 Jonathan Ashwell
Classic vs. alternative T cell p38 activation: two pathways with profoundly different biological consequences

09:20 – 09:40 Naomi Taylor
Fueling T cell activation and differentiation

09:40 – 10:00 Mitchell Kronenberg
Recognition of microbial and self lipid antigens by invariant natural killer T cells

10:00 – 10:10 Axel Kallies
IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells

10:10 – 10:20 Julian Dyson
Role of the T cell receptor germline complementarity determining regions

10:20 – 10:30 Shizuka Ohtsuka
Dual effects of ERK pathway on the clonal expansion of antigen specific CD4+ T cells

10:30 – 10:40 Rosie Hart
Lymphoid stress-surveillance: epidermal Skint1 regulates intraepithelial γδ T cells

10:40 – 10:50 Leonid Pobezinsky
Lethal-7 miRNAs control survival of developing T cells


Session 11. T cell activation and effector functions (Chaired by Takashi Saito and Makio Iwashima)

11:10 – 11:30 Takashi Saito
Direct activation of T cells by nucleic acids induces Th2 differentiation

11:30 – 11:50 Mark Bix
Host resistance to a gastrointestinal parasite regulated by a SNP modulating SMAD3 binding to a TGFβ-responsive transcriptional enhancer of Mina

11:50 – 12:10 Makio Iwashima
Schnrri-3 is required for early TH2 differentiation of CD4 T cells

12:10 – 12:30 Shinya Tanaka
Tripartite motif-containing 33 (Trim33) determines a pathogenic function of Th17 cells

12:30 – 12:40 Hiroyuki Hosokawa
Functionally distinct Gata3/Chd4 complexes coordinately establish Th2 cell identity

12:40 – 12:50 Takuya Uehata
Malt1-induced cleavage of Regnase-1 in CD4 helper T cells regulates immune activation


Session 12. Innate cells (chaired by Janko Nikolich-Zuguch and Masakatsu Yamashita)

14:00 – 14:20 Shigeo Koyasu
Critical role of p38 and GATA3 in natural helper cell differentiation and function

14:20 – 14:40 Shinichiro Sawa
Do RORγt+ innate lymphoid cells play critical role on the intestinal immunity?

14:40 – 15:00 Albert Bendelac
Transcriptional control of innate lymphoid effector programs

15:00 – 15:10 Cheong-Hee Chang
mTOR2 regulates the development and function of iNKT cells and innate-like CD4 T cells

15:10 – 15:20 Yasutaka Motomura
IL-4 derived from basophil play a pivotal role in cysteine protease-induced natural helper cell-mediated lung inflammation

15:20 – 15:30 Kazuyo Moro
TSLP induces corticosteroid resistance of natural helper cell and evokes severe asthma

15:40 Walk through Heian Jingu

18:00 Party with dinner, sake-tasting, and music at Felicita Sanjokiyamachi

Friday 7 June

Session 13. T cell memory (chaired by Charles Surh and Toshinori Nakayama)

09:00 – 09:20 Toshinori Nakayama
Pathogenic memory Th2 cells in the airway

09:20 – 09:40 Jonathan Sprent
An immunological paradox: memory T cells have reduced sensitivity to antigen

09:40 – 10:00 Charles Surh
The origin of spontaneously emerging memory phenotype CD4+ T cells

10:00 – 10:10 Masato Kubo
Roles of follicular helper T cells in antibody based protective immunity against influenza virus

10:10 – 10:20 Willam Agace
Dendritic cell expression of IRF4 is critical for intestinal CD103+CD11b+ DCs survival and Th17 cell development


Session 14. Aging and senescence (chaired by Nagahiro Minato and Richard Boyd)

10:50 – 11:10 Janko Nikolich-Zugich
Who’s naïve now? T cell pool maintenance with aging in mice and humans

11:10 – 11:30 Howard Petrie
Stromal catalase deficiency is the primary lesion in premature atrophy of the thymus

11:30 – 11:50 Nagahiro Minato
Role of senescence-associated T cells in systemic autoimmune disease

11:50 – 12:10 Kiki Tesselaar
T cell maintenance in aging, a mouse man divide

12:10 – 12:20 Masakastu Yamashita
Crucial role of Menin in the regulation of CD4 T cell terminal differentiation and senescence


Session 15. Immune microenvironments (chaired by Jorge Caamano and Ryo Goitsuka)

13:30 – 13:50 Takashi Nagasawa
The adipo-osteogenic progenitor CAR cells function as niches for hematopoietic stem and progenitor cells in the marrow

13:50 – 14:10 Koichi Ikuta
Visualization of the immune microenvironment by reporter mice

14:10 – 14:30 Ryo Goitsuka
A new mouse line for dissecting the lineage relationship and functions of mesenchymal cell components consisting of the spleen microenvironment

14:30 – 14:40 Joanna Groom
CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation

14:40 – 14:50 Hiroshi Ohno
Commensal microbe-derived butyrate induces colonic regulatory T cells


Session 16. Immune synthesis (chaired by Marcel van den Brink and Keiko Udaka)

15:10 – 15:30 Marcel van den Brink
Strategies to enhance thymic and extrathymic T cell reconstitution

15:30 – 15:50 Jorge Caamano
Signaling through TNF receptor family members during lymphoid tissue development and inflammation

15:50 – 16:10 Takeshi Watanabe
Trials toward synthesis of artificial lymphoid tissues

16:10 – 16:20 Keiko Udaka
The in vivo presentation of tumor antigens by endothelial cells guides infiltration of Th and CTLs into solid tumors

16:20 – 16:30 Noriko Tsuji
Beta-glucan in diet induces IL-10-producing regulatory CD4+ T cells (Tr1-like cells) in Peyer’s patches and protects mice from experimental colitis

Closing remarks by Shigeo Koyasu


Nuno Alves
Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo

Song Baik
Generation of both cortical and Aire+ medullary thymic epithelial compartments from CD205+ progenitors

Benjamin Blyth
Gene signatures in radiation-induced T cell lymphomas

Marco Craveiro
The NAD-dependent deacetylase Sirt1 is a critical mediator of the metabolic shift induced by T cell activation

Jan Dobes
Enteric alpha-defensins as clinically relevant intestinal autoantigens in APECED

Batu Erman
CD8 lineage specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1

Shinji Fujimoto
Analysis of Tcrb gene rearrangement in spleen tumors from Mlh1-deficient mice

Alan Hanash
Regulation of thymopoiesis during GVHD by IL-22 and innate lymphoid cells

Takahiro Hara
Visualization and characterization of IL-7- and IL-15-expressing cells in vivo

Yohsuke Harada
Role of Notch signal in function and generation of T follicular helper and memory T cells

Norihito Hayatsu
Genome-wide analysis of Foxp3-dependent transcriptional program in Treg cells using hypomorphic Foxp3 mutant mice

Tracy Heng
Establishing durable transplantation tolerance in the aged

Shinobu Hirano
Radiation response and cellular re-population kinetics of thymocytes in neonatal B6C3F1 mice

Satoshi Hirose
The Bcl11b transcription factor prevents the intrathymic development of innate CD8 T cells

Keiji Hirota
T cell-dependent mucosal IgA production by TH17 cells

Mirelle Huijskens
A novel factor promotes human T cell development in a cell free system

Hidekatsu Iha
High resolution lectin microarray system for the typing of adult T-cell leukemia and the evaluation of anti-cancer efficacy of medications

Atsushi Irie
Novel HLA-DR4 transgenic mice that spontaneously develop colitis with serious defects in lymphoid organs

Toshihiro Ito
Anti-tumor effect of BCG-LM was induced by activation of eosinophils and effector memory Th2 cells

William Jenkinson
Expression of CD205 in thymic microenvironments is dispensable for normal T-cell development

Shizuko Kakinuma
Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell

Nicole Kane-Maguire
Live-cell imaging of thymocytes and T cells – Dual-reporter transgenic Xenopus laevis model for non-invasive quantitation of ‘capacity’ and ‘competency’ in T cell development

Korosh Kianizad
Foxn1 is a direct transcriptional regulator of delta-like 4 in thymic stromal cells

Kazuyoshi Kohu
Runx1 is necessary for T cells, but NOT all the time

Philaretos Kousis
Canonical Notch1 signaling in positive selection interferes with transcriptional CD4 specification networks and T-cell migration to lymphoid organs

Jun-Young Lee
Both self and foreign antigens induce spontaneous proliferation of regulatory T cell in chronically lymphopenic hosts

Enkhsaikhan Lkhagvasuren
Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells

Susanne Lindgren
Human thymic epithelial cells release exosomes carrying TRAs

Vanja Lundberg
Exosomes stimulate maturation of single positive CD4+ thymocytes

Marcin ?yszkiewicz
New model to define thymic progenitor niches

Nancy Manley
CASA: A new method for quantifying tissue organization

Kyoko Masuda
Regeneration of human tumor antigen-specific T cells using the iPSC technology

Carlos Mayer
Epigenetics in thymic epithelial cells: The role of DNA methylation

Ryo Nakahara
Homeodomain transcription factor Tlx1 marks a unique population of postnatal spleen mesenchymal cells

Akihito Nakajima
Involvement of commensal bacteria in thymic Aire expression

Naoko Negishi
Serial transfer of anergy status induced by TSST-1 into newly stimulated T cells

Reiko Onish
Innate adaptor molecule, IPS-1, is involved in regulating productions of IL-17 and IL-22 from Th17 cells

Amiya Patra
Interleukin-7 mediated NFAT activation is critical for early thymocyte development

Marc Riemann
Regulation of autoimmunity by RelB in medullary thymic epithelium and dendritic cells

Sophia Sarafova
Identification of a novel, developmental-stage-specific enhancer in the Cd4 gene

Takaharu Sasaki
The role of Natural Helper cells in obesity-associated insulin resistance

Masashi Satoh
The preventive effect of a novel ligand for natural killer T cells in the development of experimental autoimmune uveoretinitis in mice

Ken-ichiro Seino
Induction of macrophage-like immunosuppressive cells from mouse ES cells that contribute to preventing allogeneic immune rejection

Arnauld Sergé
3D visualization of the mouse thymus organization in health and immunodeficiency

Moe Shiokawa
Evidence for distinct TCR signaling towards maintenance and activation of peripheral T cells

Ana Silva
Homeostatic maturation of recent thymic emigrants is critically dependent on NF-KB signaling

Katarzyna Sitnik
Phenotype, ontogeny and functional characteristics of thymic mesenchymal subsets

Masaaki Sunaoshi
Age dependent role of Ikaros and Pten mutations in radiation T-cell lymphomagenesis in mice

Michio Tomura
Characterization of effector and memory CD8+T cells migrated from virus infected skin

Todd Triplett
Targeting STAT3 signaling in T-cell acute lymphoblastic leukemia/lymphoma

Yoshihiro Ueda
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

Keisuke Wagatsuma
Differential roles of Jγ promoters and Eγ enhancers in controlling chromatin accessibility of the TCRγ locus by STAT5

Hiroshi Watarai
iNKT cells mediate airway inflammation through IL-25 and IL-18

Dong Weng
Th17, the beginning of adaptive immune, is manipulated by IL-1β and will drive silica-induced early lung inflammation

James Wing
Regulatory T-cells modulate T-follicular helper and germinal center formation via CTLA-4

Ryoji Yagi
The molecular mechanism of Th9 cell differentiation

Tomoyoshi Yamano
A role for Aire in thymic B cells?

Natalia Zi?tara
Critical role for miR-181a/b-1 in agonist selection of invariant NKT cells

Go back to the KTCC top page

Last update; June 25, 2013